Brevetoxin Totally Explained

Everything about Brevetoxin totally explained

Brevetoxin, or brevetoxins, are a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis. Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as Neurotoxic Shellfish Poisoning (NSP).

	Brevetoxin A	Brevetoxin B
chemical structure
subtypes	Brevetoxin-1 (PbTx-1) R = -CH₂C(=CH₂)CHO Brevetoxin-7 (PbTx-7) R = -CH₂C(=CH₂)CH₂OH Brevetoxin-10 (PbTx-10) R = -CH₂CH(-CH₃)CH₂OH	Brevetoxin-2 (PbTx-2) R = -CH₂C(=CH₂)CHO Brevetoxin-3 (PbTx-3) R = -CH₂C(=CH₂)CH₂OH Brevetoxin-8 (PbTx-8) R = -CH₂COCH₂Cl Brevetoxin-9 (PbTx-9) R = -CH₂CH(CH₃)CH₂OH

Other Brevetoxins:

Brevetoxin-5 (PbTx-5): like PbTx-3, but acetylated hydroxyl group in position 38.

Brevetoxin-6 (PbTx-6): like PbTx-2, but double bond 27-28 is epoxidated. Brevetoxin-2 was synthesized in 1995 by K.C. Nicolau and coworkers in 123 steps with 91% average yield (final yield ~9·10^-6).

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